Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity
Bocchetta, M; Di Resta, I; Powers, A; Fresco, R; Tosolini, A; Testa, J; Pass, H; Rizzo, P; Carbone, M
HERO ID
709590
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 709590 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity |
| Authors | Bocchetta, M; Di Resta, I; Powers, A; Fresco, R; Tosolini, A; Testa, J; Pass, H; Rizzo, P; Carbone, M |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 97 |
| Issue | 18 |
| Page Numbers | 10214-10219 |
| Abstract | Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the semipermissive infection thought to be characteristic of human cells. Mesothelial cells are uniformly infected but not lysed by SV40, a mechanism related to p53, and undergo cell transformation at an extremely high rate. Exposure of mesothelial cells to asbestos complemented SV40 mutants in transformation. Our data provide a mechanistic explanation for the ability of SV40 to transform mesothelial cells preferentially and indicate that asbestos and SV40 may be cocarcinogens. |
| Doi | 10.1073/pnas.170207097 |
| Pmid | 10954737 |
| Wosid | WOS:000089067500072 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Carcinogens; Tumor Suppressor Protein p53; Asbestos; 1332-21-4; Index Medicus; Cells, Cultured; Fibroblasts -- virology; Tumor Suppressor Protein p53 -- genetics; Fibroblasts -- drug effects; Fibroblasts -- cytology; Tumor Suppressor Protein p53 -- metabolism; Mesothelioma -- etiology; Mesothelioma -- virology; Mesothelioma -- pathology; Epithelial Cells -- pathology; Cell Transformation, Neoplastic; Carcinogens -- toxicity; Epithelial Cells -- drug effects; Epithelial Cells -- virology; Simian virus 40; Asbestos -- toxicity |
| Is Qa | No |
| Relationship(s) |
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