Sensory irritation by airborne chemicals
Alarie, Y
HERO ID
70967
Reference Type
Journal Article
Subtype
Review
Year
1973
Language
English
PMID
| HERO ID | 70967 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1973 |
| Title | Sensory irritation by airborne chemicals |
| Authors | Alarie, Y |
| Journal | CRC Critical Reviews in Toxicology |
| Volume | 2 |
| Issue | 3 |
| Page Numbers | 299-363 |
| Abstract | In this review an attempt is made to integrate our knowledge about sensory receptors lining the respiratory tract and the reflex reactions evoked following their stimulation by inhaled chemicals. The nature of the chemicals capable of eliciting sensory irritation and the mechanisms proposed for their interactions with nerve endings are reviewed. Methods proposed for evaluation of the effects of airborne chemicals in animals are reviewed and their usefulness for predicting the reactions to be expected in humans is evaluated. The application of these methods in industrial hygiene also discussecl. Articles reviewed Include mainly those concerned with acute exposures and the effects of the chemicals following stimulation of nervous structures in the respiratory tract. Other actions of inhaled chemicals such as their effect on ciliary motion, mucous secreting cells, etc. are excluded. Airborne chemicals can also impinge on the cornea and skin. Their action on nerve endings in these structures is compared with their action on nerve endings in the upper respiratory tract in an attempt to integrate the results obtained for chemicals capable of stimulating the "common chemical sense" receptor. |
| Doi | 10.3109/10408447309082020 |
| Pmid | 4131690 |
| Url | https://search.proquest.com/docview/82157877?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | CRC Crit. Rev. Toxicol. 2: 299-363. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Acetates; Irritants; Nitro Compounds; Sulfhydryl Compounds; Sulfuric Acids; Vehicle Emissions; Sulfur Dioxide; 0UZA3422Q4; Formaldehyde; 1HG84L3525; Acrolein; 7864XYD3JJ; Index Medicus; Reflex -- drug effects; Sensory Receptor Cells -- drug effects; Sulfuric Acids -- pharmacology; Acrolein -- pharmacology; Hemodynamics -- drug effects; Structure-Activity Relationship; Sulfhydryl Compounds -- metabolism; Acetates -- pharmacology; Taste Buds -- drug effects; Dose-Response Relationship, Drug; Neurons, Afferent -- drug effects; Tobacco; Nitro Compounds -- pharmacology; Respiratory System -- metabolism; Sensory Receptor Cells -- cytology; Formaldehyde -- pharmacology; Respiration; Sulfur Dioxide -- pharmacology; Taste Buds -- cytology; Plants, Toxic; Respiratory System -- drug effects; Irritants -- pharmacology; Air Pollution; Irritants -- metabolism |
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