Biological effects of tremolite
Wagner, J; Chamberlain, M; Brown, R; Berry, G; Pooley, F; Davies, R; Griffiths, D
HERO ID
709675
Reference Type
Journal Article
Year
1982
Language
English
PMID
| HERO ID | 709675 |
|---|---|
| In Press | No |
| Year | 1982 |
| Title | Biological effects of tremolite |
| Authors | Wagner, J; Chamberlain, M; Brown, R; Berry, G; Pooley, F; Davies, R; Griffiths, D |
| Journal | British Journal of Cancer |
| Volume | 45 |
| Issue | 3 |
| Page Numbers | 352-360 |
| Abstract | Tremolite is an amphibole which has been implicated in a variety of disease patterns in different parts of the world. It occurs in a number of phases, which are chemically identical but have specific physical characteristics. In an attempt to clarify the epidemiological findings, tremolite fibres of 3 specific forms--A, B and C--were characterized and studied for biological activity by: (i) in vivo intrapleural injection of rats (2 separate experiments--1 with poor survival). (ii) in vitro enzyme release from mouse peritoneal macrophages (iii) in vitro giant-cell formation in A549 cultures (iv) in vitro cytotoxicity for V79-4 cells. Sample C, which contained more long thin fibres than A and B, was alone in producing mesotheliomas. C, but not A or B, induced LDH and B-glucuronidase enzyme release, and induced giant cells. A was not cytotoxic, B moderately cytotoxic and C as highly cytotoxic as UICC crocidolite. The in vivo studies were marred by being split between 2 experiments, of which the second had poor survival. We are aware of the weakness of our in vivo data, but as Tremolite C was being considered for commercial use on the European market we felt it timely to submit our findings for publication. |
| Doi | 10.1038/bjc.1982.61 |
| Pmid | 6280741 |
| Wosid | WOS:A1982NJ81100004 |
| Url | http://www.nature.com/articles/bjc198261 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Asbestos, Amphibole; Silicic Acid; 1343-98-2; tremolite; 14567-73-8; Silicon Dioxide; 7631-86-9; Index Medicus; Cell Line; Cricetinae; Cricetulus; Neoplasms, Experimental -- etiology; Macrophages -- enzymology; Rats, Inbred Strains; Particle Size; Animals; Mutagenicity Tests; Mesothelioma -- etiology; Silicic Acid -- adverse effects; Silicon Dioxide -- adverse effects; Lung Neoplasms -- etiology |
| Is Qa | No |