Deposition and clearance of inhaled particles
Schlesinger, RB
| HERO ID | 72320 |
|---|---|
| Year | 1989 |
| Title | Deposition and clearance of inhaled particles |
| Book Title | Concepts in Inhalation Toxicology |
| Authors | Schlesinger, RB |
| Editor | RO McClelln; RF Henderson |
| Publisher Text | Taylor & Francis |
| City | Washington, DC |
| Page Numbers | 191-224 |
| Abstract | The biologic effects of inhaled particles are a function of their disposition. This, in turn, depends on their patterns of both deposition-i.e., the sites within which they initially come into contact with airway epithelial surfaces and the amounts removed from the inhaled air at these sites-and clearance-i.e., the rates and routes by which deposited particles are physically removed from the respiratory tract. For materials that exert their action upon surface contact, such as irritants, the initial deposition is the predicator of toxic response. In many other cases, however, it is the net result of deposition and clearance-namely, retention or the amount of particles remaining in the respiratory tract at specific times after exposure-that controls toxicity. This chapter provides a basic overview of the processes by which airborne particles are deposited within and cleared from the respiratory tract. |
| Is Certified Translation | No |
| Dupe Override | No |
| Edition | 2 |
| Comments | ECRIB.Environ. Sci. Technol. 8: 131-135. |
| Is Public | Yes |
| Is Qa | No |
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