Synthesis of hydroxy-alpha-sanshool
Zhou, J; Xiao, Yan; Chen, T; Gao, J; Huang, W; Li, Z; ,
| HERO ID | 7696153 |
|---|---|
| In Press | No |
| Year | 2021 |
| Title | Synthesis of hydroxy-alpha-sanshool |
| Authors | Zhou, J; Xiao, Yan; Chen, T; Gao, J; Huang, W; Li, Z; , |
| Journal | Journal of Chemical Research |
| Volume | 45 |
| Issue | 3-4 |
| Page Numbers | 310-314 |
| Abstract | Hydroxy-alpha-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2E,4E-hexadienal being reacted with the appropriate ylides. Impurities in the processes could easily be separated. Ethyl 6-hydroxy-2Z-hexenoate was converted to its E-isomer with catalysis by I-2 and 2E,6Z,8E,10E-dodecatetraenoic acid was crystallized from a solution in 1% ethyl acetate in n-hexane. |
| Doi | 10.1177/1747519820974323 |
| Wosid | WOS:000649144500016 |
| Url | http://journals.sagepub.com/doi/10.1177/1747519820974323 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Hydroxy-α-sanshool; synthesis; Wittig reaction |