Acute dermal toxicity study of ethyl-tert-butyl ether (ETBE) in rabbits
| HERO ID | 77017 |
|---|---|
| Year | 1989 |
| Title | Acute dermal toxicity study of ethyl-tert-butyl ether (ETBE) in rabbits |
| Authoring Organization | IIT Research Institute |
| Publisher Text | IIT Research Institute, Life Sciences Research under contract to Amoco Corporation |
| City | Chicago, IL |
| Abstract | SUMMARY Ethyl-tert-Butyl Ether (ETBE) was applied at a dose of 2 g/kg of body weight to thes haved backs of five male and five female rabbits. The test article was left in contact with the skin for 24 hours and then removed. The rabbits were observed during this time and for 14 days thereafter. No deaths occurred during the study. Therefore, the acute median lethal dermal dose (LD50) was estimated to be greater than 2 g/kg of body weight. Dermal irritation (i.e., edema, erythenia and/or eschar formation) was observed within the application sites of all rabbits following unwrapping. Mean body weight increased during the study. No gross pathological lesions attributable to treatment were evident in any of the rabbits at necropsy. |
| Report Number | Study No. 1495 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. Italicize tert.Chicago, IL: IIT Research Institute, Life Sciences Research; study no. 1495, test article no. 634; September 29. |
| Is Public | Yes |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>AMOCO CORP</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>ETHYL TERTIARY BUTYL ETHER (637-92-3)</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>HEALTH EFFECTS</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>ACUTE TOXICITY</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>MAMMALS</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>RABBITS</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>DERMAL</kw> |
| Is Qa | No |
| Relationship(s) |
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