Airway obstruction in boilermakers exposed to fuel oil ash. A prospective investigation
Hauser, R; Elreedy, S; Hoppin, JA; Christiani, DC
HERO ID
786117
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 786117 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Airway obstruction in boilermakers exposed to fuel oil ash. A prospective investigation |
| Authors | Hauser, R; Elreedy, S; Hoppin, JA; Christiani, DC |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 152 |
| Issue | 5 Pt 1 |
| Page Numbers | 1478-1484 |
| Abstract | We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SD) of 43.3 (8.6) yr. Pre-exposure spirometry and methacholine challenge tests were performed before beginning the boiler overhaul; postexposure tests were performed after approximately 4 wk of work on the boiler. Exposure to particulates with an aerodynamic diameter of 10 microns and smaller (PM10) and respirable vanadium dust were estimated using daily work diaries and a personal sampling device for respirable particles. Using these estimates, we calculated average and peak exposure between pre- and postexposure tests for each subject. The average PM10 concentration ranged from 1.44 to 6.69 mg/m3, with a mean (SD) of 3.22 (1.42) mg/m3; the average vanadium concentration ranged from 2.2 to 31.3, with a mean (SD) of 12.2 (9.1) micrograms/m3. The mean postexposure fall in FEV1 was 140 +/- 160 ml (p < 0.01); 24 of 26 subjects had a drop in FEV1. For each subject, the adjusted change in FEV1 (delta FEV1.adj) was calculated by dividing the change in FEV1 by the average of the pre- and postexposure FEV1 values. The delta FEV1.adj was regressed, controlling age and current smoking status, on average and peak exposure to both PM10 and vanadium. There was a dose-response relationship between average and peak PM10 exposure and delta FEV1.adj: beta = -0.91% per mg/m3, p = 0.08 and beta = -1.03% per mg/m3, p = 0.03, respectively. However, there was no relationship between delta FEV1.adj and respirable vanadium dust concentration. Furthermore, there was no postexposure change in nonspecific airway responsiveness. In summary, we found a significant fall in FEV1 and a dose-response relationship between delta FEV1.adj and average and peak PM10 exposure. This across-job drop in FEV1 was not associated with a shift in bronchial responsiveness as measured by methacholine. |
| Doi | 10.1164/ajrccm.152.5.7582280 |
| Pmid | 7582280 |
| Wosid | WOS:A1995TC86100008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1995TC86100008 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |