Mutagenicity evaluation of 421-32B (final report) with test data and cover letter
HERO ID
787698
Reference Type
Technical Report
Subtype
TSCA Submission
Year
1990
Language
English
| HERO ID | 787698 |
|---|---|
| Material Type | TSCA Submission |
| Year | 1990 |
| Title | Mutagenicity evaluation of 421-32B (final report) with test data and cover letter |
| Authoring Organization | Litton Bionetics |
| Publisher Text | Great Lakes Chemical Corporation |
| City | West Lafayette, IN |
| Abstract | Hexabromocyclododecane (Compound 421-32B) was evaluated for mutagenicity by plate assay in two microorganisms, Saccharomyces cerevisiae, strain D4, and Salmonella typhimurium, strains TA1535, TA1537, TA1538, TA98, and TA100, both in the presence and absence of Aroclor 1254-induced rat liver homogenate. Positive (MNNG, NF, QM, ANTH, AAF, AMQ, and DMNA) and solvent (DMSO) controls were utilized. Test concentrations ranged from 0.5 to 50 ug/plate; the low dose was less than that which demonstrated any toxic effect, and the high dose produced quantitative or qualitative evidence of some chemically-induced physiological effects. No evidence of mutagenic activity from hexabromocyclododecane was seen in any of the assays conducted in this evaluation. |
| Report Number | TSCATS/407257. OTS0523257. 86900000265 |
| Ntis Number | OTS0523257 |
| Tscats Number | TSCATS/407257 |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=OTS0523257 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: EPA ISSN: |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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