Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity
Maruyama, T; Shiba, T; Iizuka, H; Matsuda, T; Kurohane, K; Imai, Y
HERO ID
789106
Reference Type
Journal Article
Year
2007
Language
English
PMID
| HERO ID | 789106 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity |
| Authors | Maruyama, T; Shiba, T; Iizuka, H; Matsuda, T; Kurohane, K; Imai, Y |
| Journal | Microbiology and Immunology |
| Volume | 51 |
| Issue | 3 |
| Page Numbers | 321-326 |
| Abstract | Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD11b(+) dendritic cells (DC). DEP has relatively weak activity as to FITC-positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC-positive CD8alpha(+) DC in draining lymph nodes. We also found enhanced production of interleukin-4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters. |
| Doi | 10.1111/j.1348-0421.2007.tb03914.x |
| Pmid | 17380052 |
| Wosid | WOS:000244970700008 |
| Url | http://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2007.tb03914.x/abstract |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000244970700008 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; Antigens, CD45/immunology; Antigens, CD8/immunology; Dendritic Cells/ drug effects/ immunology/metabolism; Dermatitis, Contact/etiology/ immunology/metabolism; Dibutyl Phthalate/ pharmacology; Female; Fluorescein-5-isothiocyanate/administration & dosage/metabolism; Interleukin-4/ biosynthesis/immunology; Lymph Nodes/drug effects/immunology; Mice; Mice, Inbred ICR; Phthalic Acids/ pharmacology; Plasticizers/pharmacology |
| Is Qa | No |