Evaluation of the relationship between PAH content and mutagenic activity of fumes from roofing and paving asphalts and coal tar pitch
Machado, ML; Beatty, PW; Fetzer, JC; Glickman, AH; Mcginnis, EL
| HERO ID | 79613 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Evaluation of the relationship between PAH content and mutagenic activity of fumes from roofing and paving asphalts and coal tar pitch |
| Authors | Machado, ML; Beatty, PW; Fetzer, JC; Glickman, AH; Mcginnis, EL |
| Journal | Toxicological Sciences |
| Volume | 21 |
| Issue | 4 |
| Page Numbers | 492-499 |
| Abstract | BIOSIS COPYRIGHT: BIOL ABS. Fume condensates from asphalt and coal tar pitch were evaluated to determine if polycyclic aromatic hydrocarbon (PAH) composition, crude oil source, or temperature at which the fume was generated correlated with mutagenic activity. The fume condensates were tested for mutagenic activity using a modified Ames Test. Benzo(alpha)pyrene (BP) and other PAHs were detected in all samples. The concentration of BP in coal tar pitch was 18,100 ppm while the concentration in asphalt was less than 6 ppm. Coal tar fumes contained between two and three orders of magnitude more BP, as well as other PAH species, than asphalt fumes. Coal tar fume condensates were also approximately 100 times more mutagenic than those of asphalt. Generation temperature, crude oil source, and/or process conditions affected the PAH concentrations but not the mutagenicity in roofing asphalt fume condensates. With paving asphalt fumes, PAH content and mutagenicity varied with crude oil source but not with pr |
| Doi | 10.1006/faat.1993.1125 |
| Pmid | 8253302 |
| Is Certified Translation | No |
| Dupe Override | 79613 |
| Comments | Fundam. Appl. Toxicol. 21: 492-499. |
| Is Public | Yes |
| Language Text | English |
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