A PBPK modeling assessment of the competitive metabolic interactions of JP-8 vapor with two constituents, m-xylene and ethylbenzene
Campbell, JL; Fisher, JW
HERO ID
818407
Reference Type
Journal Article
Year
2007
Language
English
PMID
| HERO ID | 818407 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | A PBPK modeling assessment of the competitive metabolic interactions of JP-8 vapor with two constituents, m-xylene and ethylbenzene |
| Authors | Campbell, JL; Fisher, JW |
| Journal | Inhalation Toxicology |
| Volume | 19 |
| Issue | 3 |
| Page Numbers | 265-273 |
| Abstract | Jet Propellant 8 (JP-8) is a kerosene-based jet fuel used in the military and is composed of hundreds of hydrocarbons. A PBPK model was developed to assess the metabolic interactions of JP-8 vapor on two prominent constituents of JP-8 vapor, m-xylene (XYL) and ethylbenzene (EBZ). A limited number of rats were exposed to JP-8 vapor in a Leach chamber for 4 h to 380, 1100, or 2700 mg/m3 (total hydrocarbon). Several individual hydrocarbons were monitored in the chamber atmosphere, including XYL, EBZ, and the total hydrocarbon concentration. Blood and liver were harvested and analyzed by a novel headspace SPME/GC-MS method that allowed for identification of individual hydrocarbons and low limits of detection. The PBPK model was able to describe the metabolic interactions between XYL, EBZ, and a lumped aromatic fraction of JP-8 vapor estimated to be 18 to 25% of the fuel vapor. Competitive inhibition of XYL and EBZ metabolism was observed for JP-8 vapor inhalation exposures of 1100 and 2700 mg/m3. Future inhalation studies with jet fuel include aerosol exposures and expansion of the PBPK models to include other hydrocarbons such as n-alkanes and upper respiratory tract dosimetry of aerosol droplets. |
| Doi | 10.1080/08958370601069133 |
| Pmid | 17365029 |
| Wosid | WOS:000244925100006 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847062090&doi=10.1080%2f08958370601069133&partnerID=40&md5=c6691049663ebbe761a54e84ac4e714a |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Aerosols; Animals; Benzene Derivatives/pharmacokinetics; Hydrocarbons/pharmacokinetics; Inhalation Exposure; Male; Models, Biological; Rats; Rats, Inbred F344; Volatilization; Xylenes/pharmacokinetics; 0 (Aerosols); 0 (Benzene Derivatives); 0 (Hydrocarbons); 0 (JP8 aviation fuel); 0 (Xylenes); 100-41-4 (ethylbenzene); 108-38-3 (3-xylene) |
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