Synthesis of functionalized SBA-15 with ordered large pore size and its adsorption properties of BSA
Nguyen, TPB; Lee, JW; Shim, WG; Moon, H
| HERO ID | 854683 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Synthesis of functionalized SBA-15 with ordered large pore size and its adsorption properties of BSA |
| Authors | Nguyen, TPB; Lee, JW; Shim, WG; Moon, H |
| Journal | Microporous and Mesoporous Materials |
| Volume | 110 |
| Issue | 2-3 |
| Page Numbers | 560-569 |
| Abstract | SBA-15, mesoporous material, is a very excellent candidate for drug delivery system because its pore size is easy to control according to synthesis conditions and the presence of swelling agent. In this study, a known swelling agent, 1,3,5-trimethylbenzene (TMB), was used to increase the pore size with increased aging temperature and prolonged aging time. Furthermore, 3-aminopropyltriethoxysilane (APTES) was incorporated on SBA-15 surface via post synthesis method to separate protein effectively. The samples were characterized by X-ray diffraction (XRD), nitrogen adsorption and desorption analyses, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier Transform Infrared (FT-IR). Adsorption capacity increased with temperature at the isoelectric point (pI) of bovine serum albumin (BSA) regardless of the pore size of SBA-15 samples. Release studies were carried out in the range of pH from neutral to basic solution on unmodified and amine-modified samples. In addition, the adsorption mechanism was investigated by employing the pseudo-first order, pseudo-second order, and intraparticle diffusion models. (C) 2007 Elsevier Inc. All rights reserved. |
| Doi | 10.1016/j.micromeso.2007.06.054 |
| Wosid | WOS:000254689200043 |
| Url | http://linkinghub.elsevier.com/retrieve/pii/S1387181107004076 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | functionalized SBA-15; bovine serum albumin; adsorption; release |
| Is Qa | No |