Comprehensive long-term experimental project of carcinogenicity bioassays on gasoline oxygenated additives: plan and first report of results from the study on ethyl-tertiary-butyl ether (ETBE)
Maltoni, C; Belpoggi, F; Soffritti, M; Minardi, F
| HERO ID | 87642 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Comprehensive long-term experimental project of carcinogenicity bioassays on gasoline oxygenated additives: plan and first report of results from the study on ethyl-tertiary-butyl ether (ETBE) |
| Authors | Maltoni, C; Belpoggi, F; Soffritti, M; Minardi, F |
| Journal | European Journal of Oncology |
| Volume | 4 |
| Page Numbers | 493-508 |
| Abstract | This report illustrates the project of long-term experimental studies on the gasoline oxygenated additives and of gasoline containing several of the same oxygenates, performed by the Cancer Research Centre (CRC) of the European Ramazzini Foundation of Oncology and Environmental Sciences (RF). The compounds and mixtures studied by this project are: methyl alcohol, ethyl alcohol, methyl-tertiary-butyl ether (MTBE), ethyl-tertiary-butyl ether (ETBE), tert-amyl-methyl ether (TAME) and di-isopropyl ether (DIPE), as well as gasoline containing methyl alcohol, ethyl alcohol, MTBE and ETBE. All experiments were performed on Sprague-Dawley rats from the CRC/RF colony, exposed to test materials by ingestion (stomach intubation in extra virgin olive oil solution, or in drinking water) and kept under control until spontaneous death. The report also presents the first results of the study on ETBE. The compound was administered to groups of 120 rats (60 males and 60 females) at a daily dose of 1000, 250, and 0 (in olive oil) mg/kg b.w., for 4 days weekly, over 104 weeks. In the tested experimental conditions ETBE causes an increase in: 1) total malignant tumours (more evident in females); 2) total oncological lesions of the mouth (more evident among males); 3) total oncological lesions of the forestomach in males and, more specifically, squamocellular carcinomas in both males and females, exposed to the lower concentration of ETBE; 4) malignant uterine tumours (in particular sarcomas) in the females exposed to the lower concentration; and 5) haemolymphoreticular neoplasias (lymphomas and leukaemias), in particular lymphoimmunoblastic lymphomas. No dose-response relationship between neoplastic effects and ETBE concentrations was found: these results may be explained (at least partly) by the higher mortality in the group treated with the higher dose. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Eur. J. Oncol. 4: 493-508. |
| Is Public | Yes |
| Is Qa | No |