DNA damage in outdoor workers occupationally exposed to environmental air pollutants
Tovalin, H; Valverde, M; Morandi, MT; Blanco, S; Whitehead, L; Rojas, E
HERO ID
91322
Reference Type
Journal Article
Year
2006
Language
English
PMID
| HERO ID | 91322 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | DNA damage in outdoor workers occupationally exposed to environmental air pollutants |
| Authors | Tovalin, H; Valverde, M; Morandi, MT; Blanco, S; Whitehead, L; Rojas, E |
| Journal | Occupational and Environmental Medicine |
| Volume | 63 |
| Issue | 4 |
| Page Numbers | 230-236 |
| Abstract | BACKGROUND: Health concerns about the exposure to genotoxic and carcinogenic agents in the air are particularly significant for outdoor workers in less developed countries. AIMS: To investigate the association between personal exposure to a group of air pollutants and severity of DNA damage in outdoor workers from two Mexican cities. METHODS: DNA damage (Comet assay) and personal exposure to volatile organic compounds, PM(2.5), and ozone were investigated in 55 outdoor and indoor workers from MÚxico City and Puebla. RESULTS: In MÚxico City, outdoor workers had greater DNA damage, reflected by a longer tail length, than indoor workers (median 46.8 v 30.1 mum), and a greater percentage of highly damaged cells (cells with tail length > or =41 microm); in Puebla, outdoor and indoor workers had similar DNA damage. There were more alkali labile sites in outdoor than indoor workers. The DNA damage magnitude was positively correlated with PM(2.5) and ozone exposure. Outdoor and indoor workers with > or =60% of highly damaged cells (highly damaged workers) had significantly higher exposures to PM(2.5), ozone, and some volatile organic compounds. The main factors associated with the highly damaged workers were ozone, PM(2.5), and 1-ethyl-2-methyl benzene exposure. CONCLUSIONS: With this approach, the effects of some air pollutants could be correlated with biological endpoints from the Comet assay. It is suggested that the use of personal exposure assessment and biological endpoints evaluation could be an important tool to generate a more precise assessment of the associated potential health risks. |
| Doi | 10.1136/oem.2005.019802 |
| Pmid | 16556741 |
| Wosid | WOS:000236224300003 |
| Url | https://oem.bmj.com/lookup/doi/10.1136/oem.2005.019802 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.DNA damage in outdoor workers occupationally exposed to environmental air pollutants.Occup. Environ. Med. 63: 230-236. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Occupational Health And Safety; Solvents; Other exposures; ALS, alkali labile sites; DNA, deoxyribonucleic acid; OVMs, organic vapour monitors; OR, odds ratio; O[subscript]3[/subscript], ozone; PM, particulate matter; PM[subscript]2.5[/subscript], particulate matter with mass mean diameter [= or <, slanted]2.5 μm; PM[subscript]10[/subscript], particulate matter with mass mean diameter [= or <, slanted]10 μm; SCGE, single cell gel electrophoresis; TL, tail length; VOCs, volatile organic compounds; Volatile organic compounds--VOCs; Outdoors; Carcinogens; Pollutants; Developing countries--LDCs; Urban areas; Tobacco smoke; Outdoor activities; DNA damage; Oxidative stress |
| Is Qa | No |