Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility
O'Neill, MS; Veves, A; Sarnat, JA; Zanobetti, A; Gold, DR; Economides, PA; Horton, ES; Schwartz, J
HERO ID
91362
Reference Type
Journal Article
Year
2007
Language
English
PMID
| HERO ID | 91362 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility |
| Authors | O'Neill, MS; Veves, A; Sarnat, JA; Zanobetti, A; Gold, DR; Economides, PA; Horton, ES; Schwartz, J |
| Journal | Occupational and Environmental Medicine |
| Volume | 64 |
| Issue | 6 |
| Page Numbers | 373-379 |
| Abstract | BACKGROUND: Particulate air pollution has been associated with several adverse cardiovascular health outcomes, and people with diabetes may be especially vulnerable. One potential pathway is inflammation and endothelial dysfunction-processes in which cell adhesion molecules and inflammatory markers play important roles. AIM: To examine whether plasma levels of soluble intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and von Willebrand factor (vWF) were associated with particle exposure in 92 Boston area residents with type 2 diabetes. METHODS: Daily average ambient levels of air pollution (fine particles (PM2.5), black carbon (BC) and sulphates) were measured approximately 500 m from the patient examination site and evaluated for associations with ICAM-1, VCAM-1 and vWF. Linear regressions were fit to plasma levels of ICAM-1, VCAM-1 and vWF, with the particulate pollutant index, apparent temperature, season, age, race, sex, glycosylated haemoglobin, cholesterol, smoking history and body mass index as predictors. RESULTS: Air pollutant exposure measures showed consistently positive point estimates of association with the inflammatory markers. Among participants not taking statins and those with a history of smoking, associations between PM(2.5), BC and VCAM-1 were particularly strong. CONCLUSIONS: These results corroborate evidence suggesting that inflammatory mechanisms may explain the increased risk of air pollution-associated cardiovascular events among those with diabetes. |
| Doi | 10.1136/oem.2006.030023 |
| Pmid | 17182639 |
| Wosid | WOS:000246594300004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility.Occup. Environ. Med. 64: 373-379. |
| Is Public | Yes |
| Language Text | English |
| Keyword | CORONARY-HEART-DISEASE;INTERCELLULAR-ADHESION MOLECULE-1;ENDOTHELIAL FUNCTION;ATRIAL-FIBRILLATION;RISK;PARTICLES;ASSOCIATION;EXPOSURE;MARKERS;BLOOD;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH |
| Is Qa | No |