Mammalian toxicity of munitions compounds phase I: Acute oral toxicity, primary skin and eye irritation, dermal sensitization, disposition and metabolism and Ames tests of additional compounds
Ellis, HV; Hodgson, JR; Hwang, SW; Halpap, LM; Helton, DO; Andersen, BS; VanGoethem, DL; Lee, CC
HERO ID
9494559
Reference Type
Technical Report
Year
1978
Language
English
| HERO ID | 9494559 |
|---|---|
| Year | 1978 |
| Title | Mammalian toxicity of munitions compounds phase I: Acute oral toxicity, primary skin and eye irritation, dermal sensitization, disposition and metabolism and Ames tests of additional compounds |
| Authors | Ellis, HV; Hodgson, JR; Hwang, SW; Halpap, LM; Helton, DO; Andersen, BS; VanGoethem, DL; Lee, CC |
| Publisher Text | Midwest Research Institute |
| City | Kansas City, MO |
| Abstract | Tests indicated that 3,5-Dinitrotoluene (3,5-DNT) was the most potent of all DNT isomers in oral acute doses to rats and mice. 2-Amino-4, 6-DNT (2-ADNT) and its isomer, 4-ADNT, were the least potent in rats and female mice, and comparable to 2,3-DNT and 2,4-DNT in male mice. 3.5-DNT and 4-ADNT were not irritating to rabbit skin; 2-ADNT was a mild irritant. All three compounds were not irritating to rabbit eyes and not sensitizing to guinea pigs. 3,5-DNT and 4-ADNT were absorbed from the gastrointestinal tract, metabolized and excreted in the urine. In the Ames test, 1,3-dinitroglycerin (1,3-DNG), 1-mononitroglycerin (1-MNG), nitrocellulose and white phosphorus were not mutagenic. Trinitrotoluene (TNT) 2,4-DNT, 2,5-DNT, tetranitromethane (TNM) and 1,2-DNG were mutagenic at 10 to 30 microgram/plate in one or more strains. TNM was bactericidal without activation. 1,2-DNG was nonmutagenic with activation. 2,3-DNT, 2,6-DNT, 3,5-DNT, trinitroglycerin and 2-MNG were weakly mutagenic, with mutagenic results at 100 or 1,000 microgram/plate in one or more strains. |
| Report Number | 3900-B |
| Ntis Number | NTIS/ADA069333 |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/ADA069333.xhtml |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 48 |
| Comments | Additional URL: https://apps.dtic.mil/sti/pdfs/ADA069333.pdf Contract no. DAMD-17-74-C-4073 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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