Brain lipid changes after organic solvent exposure
Kyrklund, T; Haglid, KG
HERO ID
95237
Reference Type
Book/Book Chapter
Year
1990
Language
English
PMID
| HERO ID | 95237 |
|---|---|
| Year | 1990 |
| Title | Brain lipid changes after organic solvent exposure |
| Book Title | Berzelius Symposium XVI: Dietary lipids and the central nervous system |
| Authors | Kyrklund, T; Haglid, KG |
| Editor | Levin, Ö; Boström, H; Hallgren, B |
| Publisher Text | Almqvist & Wiksell |
| City | Stockholm, Sweden |
| Page Numbers | 267-277 |
| Abstract | Animals (rats, gerbils and guinea pigs) were exposed to various common solvents. The brain lipids were extracted and analysed. In particular the fatty acid pattern of a major phospholipid, ethanolamine, phosphoglyceride was studied. A major finding was that some chlorinated solvents, trichloroethylene, perchloroethylene and 1,1,1-trichloroethane, had effects on the ethanolamine phosphoglyceride fatty acid pattern, while most other solvents, like toluene, xylene, white spirit and Freon 11 lacked this effect. Relatively small, but significant, changes were observed in the proportions of the polyunsaturated fatty acids of both the n-6 and n-3 series. The selective effect of the chlorinated solvents might indicate that they have a specific effect on the enzymatic regulation of membrane fatty acid composition. However, the lack of effects of other solvents might also be explained by low blood levels, due either to a low uptake (Freon 11, white spirit) or an extensive metabolism (toluene, xylene). Intrauterine exposure of guinea pigs to perchloroethylene (160 ppm) during the last half of gestation had minor effects on the ethanolamine phosphoglyceride fatty acid pattern. Thus it appears that animals during the period of rapid brain growth are equally sensitive to exposure as adult animals. |
| Pmid | 2077699 |
| Wosid | WOS:A1990ET15200015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Stockholm, Sweden |
| Series | Upsala Journal of Medical Sciences Supplement, no. 48 |
| Conference Name | Symposium on Dietary Lipids and the Central Nervous System |
| Conference Date | November 2-3, 1988 |
| Comments | Source: https://search.proquest.com/docview/80284241?accountid=171501 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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