Pathological role of Nox proteins
Miller, F
HERO ID
975848
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 975848 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | Pathological role of Nox proteins |
| Authors | Miller, F |
| Journal | Free Radical Biology and Medicine |
| Volume | 45 |
| Issue | Suppl. |
| Page Numbers | S9-S9 |
| Abstract | In vascular cells, the NADPH oxidases contribute to normal physiologic signaling and have been identifi ed as a primary source of “oxidative stress” and pathologic redox activation in cardiovascular disease. The Nox subunits represent the catalytic site of NADPH oxidase and are responsible for generation of superoxide. We will discuss the expression and function of the various Nox homologs and their potential role in the development of cardiovascular disease. Data will also be reviewed discussing the compartmentalization of Nox-derived reactive oxygen species as a mechanism for providing specifi city in cell signaling. Finally, we will review recent data demonstrating that changes in extracellular redox potential will induce Nox1 expression through signal transduction pathways involving EGFR. |
| Wosid | WOS:000260867900017 |
| Url | http://www.sciencedirect.com/science/article/pii/S0891584908006187 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Indianapolis, IN |
| Conference Name | Society for Free Radical Biology and Medicine 15th Annual Meeting |
| Conference Date | November 19-23, 2008 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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