The aerobic one-electron oxidation of ferrocytochrome C by peroxynitrite is an oxygen-dependent reaction that does not involve carbonate radical
Peterson, J; Lopez-Manzano, E; Pearce, LL
HERO ID
975860
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 975860 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | The aerobic one-electron oxidation of ferrocytochrome C by peroxynitrite is an oxygen-dependent reaction that does not involve carbonate radical |
| Authors | Peterson, J; Lopez-Manzano, E; Pearce, LL |
| Journal | Free Radical Biology and Medicine |
| Volume | 45 |
| Issue | Suppl. |
| Page Numbers | S62-S62 |
| Abstract | The mitochondrial electron transport chain (ETC) can readily undergo redox reactions with a variety of organic and inorganic species, including peroxynitrite, preferentially a two-electron oxidant. There is a good deal of evidence supporting the interaction of peroxynitrite with carbon dioxide in physiological fluids, leading to the generation of carbonate radical, a one-electron oxidant. Therefore, the question of whether peroxynitrite appears to act as a one- or two-electron oxidant towards metalloenzymes, like those of the ETC, is of some interest. We find that peroxynitrite appears to behave as a one-electron oxidant towards ferrocytochrome c, but the reaction seems to be independent of carbon dioxide. This is in good agreement with the earlier findings of others [Arch. Biochem. Biophys. (1996) 333, 49-58]. However, more surprisingly, the reaction shows a clear dependence on the presence of oxygen. in contrast, the reaction of peroxynitrite with ferrocyanide, also a one-electron process, is both oxygen and carbon dioxide independent. the mechanistic role of oxygen in one-electron oxidations by peroxynitrite is currently under further investigation. |
| Wosid | WOS:000260867900171 |
| Url | http://www.sciencedirect.com/science/article/pii/S0891584908006230 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Indianapolis, IN |
| Conference Name | Society for Free Radical Biology and Medicine 15th Annual Meeting |
| Conference Date | November 19-23, 2008 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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