Combined effects of nitric oxide and hypoxia on breast cancer cell migration
Hickok, JR; Sahni, S; Krock, KM; Thomas, DD
HERO ID
975861
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 975861 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | Combined effects of nitric oxide and hypoxia on breast cancer cell migration |
| Authors | Hickok, JR; Sahni, S; Krock, KM; Thomas, DD |
| Journal | Free Radical Biology and Medicine |
| Volume | 45 |
| Issue | Suppl. |
| Page Numbers | S53-S53 |
| Abstract | Tumor cell invasion is a major component of breast cancer aggressiveness and patient mortality. Although there are a variety of factors that contribute to invasive phenotypes, nitric oxide (NO) plays an important role in influencing the metastatic process. NO can alter tumor cell migration and invasion in either a positive or negative fashion. as these differences may simply be a function of the concentration of NO, we set out to investigate the concentration-dependent parameters of NO that differentially regulate tumor cell migration. We correlate the degree of tumor cell (MDA-MD-231) migration with the concentration and duration of NO exposure. Furthermore, we demonstrate that hypoxia (1% O2) influences the migratory potential of tumor cells by altering the steady-state concentrations of NO. Finally, using both chemical (NO donors) and biological sources (RAW 274.1 cells), we found that both the rate of NO production and its rate of metabolism are critical determinants of tumor cell migration. |
| Wosid | WOS:000260867900144 |
| Url | http://www.sciencedirect.com/science/article/pii/S0891584908006229 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Indianapolis, IN |
| Conference Name | Society for Free Radical Biology and Medicine 15th Annual Meeting |
| Conference Date | November 19-23, 2008 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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