The role of nitric oxide in the tolerance induction to LPS
Melo, ES; Barbeiro, DF; Moretti, AIS; Soriano, FG
HERO ID
975870
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 975870 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | The role of nitric oxide in the tolerance induction to LPS |
| Authors | Melo, ES; Barbeiro, DF; Moretti, AIS; Soriano, FG |
| Journal | Free Radical Biology and Medicine |
| Volume | 45 |
| Issue | Suppl. |
| Page Numbers | S136-S136 |
| Abstract | The nitric oxide has participation in the tolerance to the LPS “in vitro” and intervenes with the development of the tolerance in the macrophages, regulating the production of cytokines. This study investigated the nitric oxide role in the production of the cytokines from the macrophages in the model of tolerance to the LPS. Peritoneal macrophages were collected from nitric oxide synthase (iNOS) knock out mice (KO) or wild type (C57). Cell culture with 106 cells/ml in medium RPMI were divided in three groups: CGcontrol group, GL- stimulation with LPS (10 μg/ml) in the last 24 hours of culture, GT- stimulation with LPS (10 μg/ml) in the last 48 hours of culture. the supernatants were collected after 72 hours and analyzed by ELISA. |
| Wosid | WOS:000260867900385 |
| Url | http://www.sciencedirect.com/science/article/pii/S089158490800631X |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Indianapolis, IN |
| Conference Name | Society for Free Radical Biology and Medicine 15th Annual Meeting |
| Conference Date | November 19-23, 2008 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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