Liberation of vessel adherent myeloperoxidase by enoxaparin improves endothelial nitric oxide bioavailability
Rudolph, T; Rudolph, V; Klinke, A; Lau, D; Heitzer, T; Meinertz, T; Baldus, S
HERO ID
975871
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 975871 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | Liberation of vessel adherent myeloperoxidase by enoxaparin improves endothelial nitric oxide bioavailability |
| Authors | Rudolph, T; Rudolph, V; Klinke, A; Lau, D; Heitzer, T; Meinertz, T; Baldus, S |
| Journal | Free Radical Biology and Medicine |
| Volume | 45 |
| Issue | Suppl. |
| Page Numbers | S135-S135 |
| Abstract | Aim: Myeloperoxidase (MPO), a leukocyte-derived heme enzyme binds to the endothelium and depletes vascular nitric oxide (NO) bioavailability in animal models. Unfractionated heparins release vessel-bound MPO and increase endothelial NO bioavailability. Whether low molecular weight heparins also affect circulating MPO levels and NO dependent vasoreactivity however remains elusive. Methods and Results: in a randomized, double-blind, placebo controlled trial patients with stable coronary artery disease received either 1 mg/kg enoxaparin or an equivalent volume of sodium chloride (NaCl) subcutaneously. Enoxaparin led to a significant improvement of FMD (5.51±2.92% vs. 6.55±3.16%, p=0.01) accompanied by a significant increase in plasma MPO levels (2.51 [IR: 2.04-3.62] ng/ml vs. 3.70 [IR: 2.80-5.50] ng/ml; p<0.001) whereas NaCl revealed neither a change in FMD (5.56±3.62% vs. 5.34±3.32%, p=ns) nor in plasma MPO levels (3.04 [IR: 2.22-4.67] ng/ml vs. 2.90 [IR:1.95-4.32] ng/ml; p=ns). The extent of enoxaparin-induced MPO release and the improvement in endothelial function correlated (r=0.67, P<0.001). Conclusion: This study confirms the concept that heparins enhance vascular NO bioavailability by mobilizing vessel bound MPO. These data not only support the notion of extracoagulant, anti-inflammatory properties of heparins but reinforce the concept of MPO-dependent NO oxidation as a central mechanism for regulation of vascular tone in inflammatory vascular disease. |
| Wosid | WOS:000260867900380 |
| Url | http://www.sciencedirect.com/science/article/pii/S089158490800631X |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Indianapolis, IN |
| Conference Name | Society for Free Radical Biology and Medicine 15th Annual Meeting |
| Conference Date | November 19-23, 2008 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
|