Naphthalene (2021 Evidence mapping publication)

Project ID

3064

Category

Other

Added on

May 10, 2021, 6:59 a.m.

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Technical Report

Abstract  Four groups of 15 male and 15 female Sprague-Dawley rats were exposed, six hours a day for five consecutive days, to either clean air or 153, 471, 1540 ppm of C9 aromatic hydrocarbon vapors. A fifth group of five males and five females served as positive controls and received an injection of 40/mg/kg cyclophosphoride. Five males and five females from each exposure group were injected with 4 mg/kg colchincine, six hours later (which was 6, 24, and 48 hours after the last exposure), the animlas were sacrificed, bone marrow collected, and chormosoome spreads prepared. The positive control animals were evaluated at 24-hour intervals. Under the exposure conditions for this study, C9 aromatic hydrocarbon vapor did not induce chromosome or chromatid aberrations at any exposure level, and therefore, was considered to be non-mutagenic.

Technical Report

Abstract  The objective of this study was to determine the toxicity of naphthalene when administered to the bobwhite in the diet for five days. The study was conducted by Wildlife International Ltd. under contract to W. R. Landis Associates. Inc. The test was conducted at the Wildlife International Ltd. avian toxicology facility 1n St. Michaels, Maryland 21663. The methods used in this study are based upon ASTM Standard E857-81. ·Standard Practice for Conducting Subacute Dietary Toxicity Tests with Avian Species,· and The Environmental Protection Agency Guidelines Pesticide Assessment Guidelines, FIFRA Subdivision E. Hazard Evaluation: Wildlife and Aquatic Organisms (1,2).

Technical Report

Abstract  s included decreased activity, diarrhea, poor grooming, increased and decreased muscle tone, chromodacryorrhea, piloerection, ptosis, cyanosis, dyspnea, abnormal gait and stance, tremors, pre-convulsive behavior and prostration. Gross necropsy revealed multiple lesions in the stomach mucosa, discolored lungs, adrenals and intestines.

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