Effect of various dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet
Domingo, JL; Gomez, M; Sanchez, DJ; Llobet, JM; Corbella, J
HERO ID
1990523
Reference Type
Journal Article
Year
1993
Language
English
PMID
| HERO ID | 1990523 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Effect of various dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet |
| Authors | Domingo, JL; Gomez, M; Sanchez, DJ; Llobet, JM; Corbella, J |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 79 |
| Issue | 3 |
| Page Numbers | 377-380 |
| Abstract | The influence of some frequent dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet was investigated in mice. Eight groups of male mice received lactic (57.6 mg/kg/day), tartaric (96 mg/kg/day), gluconic (125.4 mg/kg/day), malic (85.8 mg/kg/day), succinic (75.6 mg/kg/day), ascorbic (112.6 mg/kg/day), citric (124 mg/kg/day), and oxalic (80.6 mg/kg/day) acids in the drinking water for one month. At the end of this period, animals were killed and aluminum concentrations in liver, spleen, kidney, brain, and bone were determined. All the dietary constituents significantly increased the aluminum levels in bone, whereas brain aluminum concentrations were also raised by the intake of lactic, gluconic, malic, citric, and oxalic acids. The levels of aluminum found in spleen were significantly increased by gluconic and ascorbic acids, whereas gluconic and oxalic acids also raised the concentrations of aluminum found in kidneys. Because of the wide presence and consumption of the above dietary constituents, in order to prevent aluminum accumulation and toxicity we suggest a drastic limitation of human exposure to aluminum. |
| Pmid | 8480083 |
| Wosid | WOS:A1993KU27800011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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