Plasma Metabonomic Profiling of Diabetic Retinopathy
Chen, L; Cheng, CY; Choi, H; Ikram, MK; Sabanayagam, C; Tan, GS; Tian, D; Zhang, L; Venkatesan, G; Tai, ES; Wang, JJ; Mitchell, P; Gemmy Cheung, CM; Beuerman, RW; Zhou, L; Yong Chan, EC; Wong, TY
HERO ID
3212876
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3212876 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Plasma Metabonomic Profiling of Diabetic Retinopathy |
| Authors | Chen, L; Cheng, CY; Choi, H; Ikram, MK; Sabanayagam, C; Tan, GS; Tian, D; Zhang, L; Venkatesan, G; Tai, ES; Wang, JJ; Mitchell, P; Gemmy Cheung, CM; Beuerman, RW; Zhou, L; Yong Chan, EC; Wong, TY |
| Journal | Diabetes |
| Volume | 65 |
| Issue | 4 |
| Page Numbers | 1099-1108 |
| Abstract | Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and the leading cause of visual impairment in working-age adults. Diabetic patients often develop DR despite appropriate control of systemic risk factors, suggesting the involvement of other pathogenic factors. We hypothesize a plasma metabolic signature of DR that is distinct and resolvable from that of diabetes alone. A nested population-based case-control metabonomic study was first performed on 40 DR cases and 40 diabetic controls using gas chromatography-mass spectrometry. Eleven metabolites were found to be correlated with DR, and the majority were robust when adjusted for metabolic risk factors and confounding kidney disease. The metabolite markers 2-deoxyribonic acid; 3,4-dihydroxybutyric acid; erythritol; gluconic acid and ribose were validated in an independent sample set with 40 DR cases, 40 diabetic controls and 40 non-diabetic individuals. DR cases and diabetic controls were matched by HbA1c in the validation set. Activation of the pentose phosphate pathway was identified from the list of DR metabolite markers. The identification of novel metabolite markers for DR provides insights into potential new pathogenic pathways for this microvascular complication and holds translational value in DR risk stratification and the development of new therapeutic measures. |
| Doi | 10.2337/db15-0661 |
| Pmid | 26822086 |
| Wosid | WOS:000372859200027 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |