Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy
Fan, W; Lu, N; Huang, P; Liu, Y; Yang, Z; Wang, S; Yu, G; Liu, Y; Hu, J; He, Q; Qu, J; Wang, T; Chen, X
| HERO ID | 3845301 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy |
| Authors | Fan, W; Lu, N; Huang, P; Liu, Y; Yang, Z; Wang, S; Yu, G; Liu, Y; Hu, J; He, Q; Qu, J; Wang, T; Chen, X |
| Journal | Angewandte Chemie (International Edition) |
| Volume | 56 |
| Issue | 5 |
| Page Numbers | 1229-1233 |
| Abstract | Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effect. |
| Doi | 10.1002/anie.201610682 |
| Pmid | 27936311 |
| Wosid | WOS:000394997700006 |
| Is Certified Translation | No |
| Dupe Override | 3845301 |
| Is Public | Yes |
| Language Text | English |