Long-term experiment with canned meat treated with sodium nitrite and glucono-delta-lactone in rats
van Logten, MJ; Den Tonkelaar, EM; Kroes, R; Berkvens, JM; van Esch, GJ
HERO ID
4072921
Reference Type
Journal Article
Year
1972
Language
English
PMID
| HERO ID | 4072921 |
|---|---|
| In Press | No |
| Year | 1972 |
| Title | Long-term experiment with canned meat treated with sodium nitrite and glucono-delta-lactone in rats |
| Authors | van Logten, MJ; Den Tonkelaar, EM; Kroes, R; Berkvens, JM; van Esch, GJ |
| Journal | Food and Cosmetics Toxicology |
| Volume | 10 |
| Issue | 4 |
| Page Numbers | 475-488 |
| Abstract | A long-term toxicity experiment was carried out in rats fed a diet containing 40% canned meat treated with either 0-5 or 0.02 % sodium nitrite with or without glucono-8-1actone. This experiment, in which special attention was paid to the detection of a possible carcinogenic effect, was designed to study the possible formation of nitrosamines from nitrite and the secondary amines present in meat, under the conditions of an acid pH and pasteurization. The parameters studied included haematology, clinical biochemistry, histopathology, a-foetoprotein in the serum and the DNA content of the liver cell nuclei. There was no evidence of any preneoplastic change or tumour formation that could be attributed to the feeding of this canned meat. |
| Doi | 10.1016/S0015-6264(72)80082-8 |
| Pmid | 4343302 |
| Wosid | WOS:A1972N211700003 |
| Url | <Go to ISI>://WOS:A1972N211700003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Index Medicus |
| Is Peer Review | Yes |
| Relationship(s) |
|