Evaluation of 4 animal-models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty-acids on calcification
Burgess, NA; Reynolds, TM; Williams, N; Pathy, A; Smith, S
HERO ID
4941188
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 4941188 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Evaluation of 4 animal-models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty-acids on calcification |
| Authors | Burgess, NA; Reynolds, TM; Williams, N; Pathy, A; Smith, S |
| Journal | Urological Research |
| Volume | 23 |
| Issue | 4 |
| Page Numbers | 239-242 |
| Abstract | Firstly, to determine a satisfactory animal model for induction of intrarenal calcification, a study of four previously described animal models of intrarenal calcification was carried out which showed that intraperitoneal injection of 10% calcium gluconate into female Sprague-Dawley rats was most effective. We then investigated the hypothesis that dietary supplementation with essential fatty acids could reduce the intrarenal calcification developing as a result of intraperitoneal calcium injection. Using a combination of fish oil and evening primrose oil, we demonstrated a significant difference in renal parenchymal calcification, which was 940 +/- 240 mu g Ca/g dry weight renal parenchyma in unsupplemented animals and 320-370 +/- 55-65 mu g Ca/g dry weight renal. parenchyma in supplemented animals (means +/- SEM, P < 0.005). It was also demonstrated that there was synergism between eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA): dietary supplementation with a combined oil preparation containing 27 mg/ml EPA and 67 mg/ml GLA mixed as 2% with food was as effective as oils containing either 400 mg/ml EPA or 80 mg/ml GLA mixed as 4% of food. |
| Doi | 10.1007/BF00393305 |
| Pmid | 8533210 |
| Wosid | WOS:A1995RT27600007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | INTRARENAL CALCIUM DEPOSITION; DIETARY SUPPLEMENTATION; ESSENTIAL FATTY ACIDS; CALCIFICATION |