Effects of hexoses and their derivatives on glucagon secretion from isolated perfused rat pancreas
Sumida, Y; Shima, T; Shirayama, K; Misaki, M; Miyaji, K
HERO ID
4945990
Reference Type
Journal Article
Year
1994
Language
English
PMID
| HERO ID | 4945990 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | Effects of hexoses and their derivatives on glucagon secretion from isolated perfused rat pancreas |
| Authors | Sumida, Y; Shima, T; Shirayama, K; Misaki, M; Miyaji, K |
| Journal | Hormone and Metabolic Research |
| Volume | 26 |
| Issue | 5 |
| Page Numbers | 222-225 |
| Abstract | Although it has been firmly established that D-glucose inhibits glucagon secretion from pancreatic A cells, the regulatory mechanism of glucagon secretion by D-glucose has not been elucidated. To study this regulatory mechanism by D-glucose, the effects of hexoses and their derivatives on glucagon secretion from the A cells of isolated perfused rat pancreas were investigated. When these cells were perfused with D-glucose, D-fructose, D-sorbitol, D-galactose, 2-deoxy-D-glucose, D-gluconic acid sodium salt and D-glucosamine HCl salt, glucagon secretion was significantly inhibited. None of the hexoses or their derivatives tested were found to stimulate glucagon secretion. The effects of these sugars on glucagon secretion were independent of their metabolism in the cells. From the findings that the sugars both metabolized and unmetabolized in the cells demonstrated comparable inhibition of glucagon secretion from the isolated perfused rat pancreas, it is speculated that the recognition system for these sugars may be probably present on the A cell membrane and responsible for mediating these inhibitory effects of glucagon secretion. |
| Doi | 10.1055/s-2007-1001669 |
| Pmid | 8076903 |
| Wosid | WOS:A1994NN14400002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |