Effect of potassium gluconate on potassium transport of rat erythrocytes
Tsujitani, M; Okabe, E; Ito, H
HERO ID
4946480
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 4946480 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Effect of potassium gluconate on potassium transport of rat erythrocytes |
| Authors | Tsujitani, M; Okabe, E; Ito, H |
| Journal | Japanese Journal of Pharmacology |
| Volume | 40 |
| Issue | 1 |
| Page Numbers | 135-141 |
| Abstract | Effect of potassium gluconate (K-GL) on K+ uptake of rat erythrocytes was investigated. K-GL produced a significant increase in active K+ transport of Na+-rich erythrocytes, while Na+,K+-ATPase activity of hemoglobin-free ghosts without a glycolytic system was unaffected. When the experiment was carried out in intact erythrocytes, K-GL increased the lactate production and ATP content, and it promoted the methemoglobin reduction rate. In Na+-rich erythrocytes, the glycolysis inhibitors which produced a marked reduction in lactate content abolished the K-GL-induced increase in K+ and ATP content without affecting the KCl-induced increase. These results suggest that K-GL enhances K+ transport of erythrocytes through acceleration of glycolytic process. |
| Doi | 10.1254/jjp.40.135 |
| Pmid | 2937946 |
| Wosid | WOS:A1986AWQ9100014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |