Novel combination for the treatment of acne differentiated according to gender: a new step towards personalized treatment
Tolino, E; Skroza, N; Mambrin, A; Bernardini, N; Zuber, S; Balduzzi, V; Marchesiello, A; Proietti, I; Potenza, C
HERO ID
4946779
Reference Type
Journal Article
Year
2018
Language
English
PMID
| HERO ID | 4946779 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Novel combination for the treatment of acne differentiated according to gender: a new step towards personalized treatment |
| Authors | Tolino, E; Skroza, N; Mambrin, A; Bernardini, N; Zuber, S; Balduzzi, V; Marchesiello, A; Proietti, I; Potenza, C |
| Journal | Giornale Italiano di Dermatologia e Venereologia |
| Abstract | <strong>BACKGROUND: </strong>The aim of this study is to evaluate efficacy and tolerability of a complete skin care line consisting of an oral supplement in two distinct formulations for males and females, and a topical cream device in the treatment of mild and moderate acne. Oral supplements contain biotin, probiotic, vitamin E, zinc, nicotinamide; in the formulation for males beta sitosterol and boswella serrata were added, the oral supplement for females contains myo-inositol and folic acid. The topical cream device is represented by the association between active plant agents (verbascoside, ocimum gratissimum) and keratolytic molecules (salicylic acid, gluconolactone, complex alpha-hydroxy acids).<br /><br /><strong>METHODS: </strong>An equal number of male and female patients with mild to moderate acne were enrolled in a double-blinded clinical trial. Efficacy and tolerability evaluations were performed at week 4 (T1) and week 12 (T2) by Global acne Grading System (GAGs).<br /><br /><strong>RESULTS: </strong>Most of patients had satisfactory therapeutic response, in terms of GAGs reduction.. All the four groups presented a statistically significant improvement of the mean GAGs at T2 but those assuming the oral supplement improved more, as expected.<br /><br /><strong>CONCLUSIONS: </strong>Our data suggest that this association can be considered a new effective option for mild and moderate acne. This therapeutic line differs from others in the gender matched oral treatment. |
| Doi | 10.23736/S0392-0488.18.05710-3 |
| Pmid | 29417793 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |