In vitro effect of 6-carbon monosaccharides on the sodium channel response to crude fish extracts containing ciguatoxin
Hokama, Y; Miyahara, JT
| HERO ID | 4947747 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | In vitro effect of 6-carbon monosaccharides on the sodium channel response to crude fish extracts containing ciguatoxin |
| Authors | Hokama, Y; Miyahara, JT |
| Journal | Journal of Natural Toxins |
| Volume | 3 |
| Issue | 1 |
| Page Numbers | 35-47 |
| Abstract | BIOSIS COPYRIGHT: BIOL ABS. D-mannitol given in intravenous infusion at a dose of 0.5 to 1.0 g/kg body weight has been used in recent years for the treatment of acute ciguatera fish poisoning. The best results for relief of acute clinical symptoms are obtained when the patients are administered D-mannitol within three days of the onset of intoxication. In this study, the examination of the effects of monosaccharides on the guinea pig atrial responses stimulated by crude CTX was carried out in vitro. D-mannitol (0.27 M), D-mannose (0.28 M), and D-gluconic acid (0.25 M) concentrations had a strong inhibitory effect on the inotropic responses when given before or after crude CTX to the guinea pig atria. Final concentrations of D-mannitol (0.12 M), D-mannose (0.11 M), and D-gluconic acid (0.12 M) showed only partial inhibition. We conclude that the monosaccharides interfered at the receptor sites of the sodium channels of the guinea pig atrial tissue, but not specifically the sodium channels. |
| Is Certified Translation | No |
| Dupe Override | 4947747 |
| Is Public | Yes |
| Language Text | English |