The divalent cations calcium, manganese, barium, zinc, but not magnesium induce acute pancreatitis in the rat
Schären, S; Frick, TW; Freiburghaus, U; Largiadèr, F
HERO ID
4947751
Reference Type
Journal Article
Subtype
Abstract
Year
1991
Language
English
| HERO ID | 4947751 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1991 |
| Title | The divalent cations calcium, manganese, barium, zinc, but not magnesium induce acute pancreatitis in the rat |
| Authors | Schären, S; Frick, TW; Freiburghaus, U; Largiadèr, F |
| Journal | Pancreas |
| Volume | 6 |
| Issue | 6 |
| Page Numbers | 719 |
| Abstract | We have previously shown that local infusion of calcium, but not potassium induces acute necrotizing pancreatitis in the cat. In the present experiments the same experimental set up was used in the rat to test the effect of different divalent cations. MATERIALS AND METHODS: In anesthetized rats weighing 250-350g, the inferior splenic artery was intubated at the tail of the pancreas. Retrograde infusion (flow 0.5-l.Omlih) of Mg++ (MgCI), Ca++ (CaGluconate), Ba++ (BaCI), Mn++ (MnCI) (at 0.6mmolkgh. each), Zn++ (ZnCI, at 0.1,0.06.0.01, and0.002, mmolkgh), and NaCl 0.9% was performed. Groups of four animals were treated for three hours. RESULTS: The pancreas of animals treated with Ca-Gluconate and MnCl showed acute necrotizing pancreatitis with necrosis of acinar lobuli, hemorrhage and leucocytic infiltrates only in the perfused region at three hours. Animals treated with BaCl spontaneously died 49215 minutes after starting the experiment. They also showed pancreatitis in the perfused region, but not in the residual pancreas. ZnCl at doses of 0.1 - 0.01 mmolkgh lead to immediate blood-clotting, obstruction of capillaries, and subsequent ischemic necrosis of the pancreas. Lower ZnCl concentrations (0.002 mmolkgh) induced pancreatitis as seen after calcium. MgCl and NaCl infusion did not induce any changes in pancreas histology Serum calcium levels in Ca-treated rats were 4.0k1.6 mol/L (controls: 2.4?0.2), and serum magnesium levels in Mg-treated rats were 2.8?1.2 mom (controls: 1.320.2). CONCLUSIONS: Local infusion of the divalent cations Ca++, Mn++, Ba++. aild Zn++ leads to acute necrotizing pancreatitis in the rat within three hours, whereas Mg++ has no effect on histological appearance. |
| Wosid | BCI:BCI199242025974 |
| Url | https://journals.lww.com/pancreasjournal/Citation/1991/11000/Abstracts_of_Papers_Submitted_to_the_American.13.aspx |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Chicago, IL |
| Conference Name | American Pancreatic Association Meeting |
| Conference Date | October 31 - November 1, 1991 |
| Is Public | Yes |
| Language Text | English |