Effects of long-chain fatty acids and fatty alcohols on the growth of Streptococcus mutans
Hattori, M; Miyachi, K; Hada, S; Kakiuchi, N; Kiuchi, F; Tsuda, Y; Namba, T
HERO ID
5094367
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 5094367 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Effects of long-chain fatty acids and fatty alcohols on the growth of Streptococcus mutans |
| Authors | Hattori, M; Miyachi, K; Hada, S; Kakiuchi, N; Kiuchi, F; Tsuda, Y; Namba, T |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 35 |
| Issue | 8 |
| Page Numbers | 3507-3510 |
| Abstract | Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56 μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78 μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5 μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic, 6Z-octadecenoic, 11 Z-octadecenoic and 9Z, 12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated. |
| Doi | 10.1248/cpb.35.3507 |
| Pmid | 3427727 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |