US EPA

1005271 

Journal Article 

Abstract 

Physiological effects of nitrogen dioxide exposure and heat stress in cynomolgus monkeys 

Coate, WB; Badger, DW 

1974 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

29 

1 

130-131 

English 

WOS:A1974T653800147 

is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

In order to assess the effects of hot environments on nitrogen dioxide toxicity, groups of 10 male cynomolgus monkeys were exposed continuously for 90 days to 5 and 10 ppm of NO2 at 72° E.T. and at 88° E.T. Air control groups were maintained at the respective effective temperatures. Hematological studies included CBC, methemoglobin, plasma volume and red cell survival. Serum chemistry, blood gases, chest X-rays and body weights were monitored. Pulmonary function tests were conducted. The results indicated that NO2 at 10 ppm impaired distribution of ventilation of the lungs, increased respiratory rate, and decreased tidal volume. The addition of heat-stress to this level of NO2 exposure did not further impair distribution of ventilation but it decreased dynamic compliance of the lungs whereas NO2 alone did not. The combination of 10 ppm NO2 and heat-stress resulted in a mean loss in body weight over the 90-day exposure whereas all other groups gained weight. No effects were found on hematological or serum chemistry attributable to NO2 or heat-stress. No deleterious effects were found on blood gases from either factor. No effects on airway resistance were obtained. General observation indicated that the animals were hypoactive in the chambers at 88° E.T. with and without NO2. No synergistic effects of heat-stress were found at 5 ppm NO2. 

Thirteenth Annual Meeting of the Society of Toxicology 

Washington, DC 

March 10–14, 1974