Health & Environmental Research Online (HERO)


Print Feedback Export to File
1022193 
Journal Article 
Review 
New perspectives in arsenic-induced cell signal transduction 
Qian, Y; Castranova, V; Shi, X 
2003 
Yes 
Journal of Inorganic Biochemistry
ISSN: 0162-0134
EISSN: 1873-3344 
96 
2-3 
271-278 
English 
12888263 
WOS:000184654800001 
Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-kappaB activation, cell cycle arrest, and apoptosis. 
metal; arsenic; tyrosine phosphorylation; reactive oxygen species; cell cycle; apoptosis; MAPK; NF-kappa B 
IRIS
• Arsenic Hazard ID
     1. Initial Lit Search
          PubMed
          ToxNet
     3. Initial Filter through Oct 2015
          Reviews