US EPA

1023070 

Journal Article 

Review 

Chemical-induced inflammation and inflammatory diseases 

Parke, DV; Parke, AL 

1996 

Yes 

International Journal of Occupational Medicine and Environmental Health
ISSN: 1232-1087
EISSN: 1896-494X 

9 

3 

211-217 

English 

8972163 

MEDLINE:8972163 

Inflammatory reactions associated with exposure to chemicals and biological mechanisms responsible for such effects were reviewed. The ability of chemicals to induce inflammation has been related to the induction of cytochrome-P4502E (CYP2E) and the subsequent production of reactive oxygen species which initiate the cascade of events leading to inflammation. The possible contribution of chemical exposures to the development of common chronic inflammatory diseases including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and the acquired immunodeficiency syndrome was discussed. Chemicals which do not easily undergo oxidative metabolism such as acetone (67641), methyl-ketone-ester, diethyl-ether (60297), ethanol (64175), and benzene (71432), halogenated compounds such as halothane (151677), carbon-tetrachloride (56235), and chloroform (67663), and dialkyl nitrosamines such as diethylnitrosamine (55185) and dimethylnitrosamine (62759) have all been characterized as CYP2E substrates. Other chemicals such as procainamide (51069), hydralazine (86544), sulfasalazine (599791), and sulfonamides have been postulated to produce reactive intermediates which may form immune complexes inducing inflammation as well as exerting immunotoxic effects. Specific examples of chemical induced inflammatory syndromes were described.