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1023390 
Journal Article 
Comparative acute toxicity of the first 50 multicentre evaluation of in vitro cytotoxicity chemicals to aquatic non-vertebrates 
Calleja, MC; Persoone, G; Geladi, P 
1994 
Yes 
Archives of Environmental Contamination and Toxicology
ISSN: 0090-4341
EISSN: 1432-0703 
26 
1 
69-78 
English 
WOS:A1994ML24900011 
uses data from 9959481 Cyst-based toxicity tests. IV. The potential of ecotoxicological tests for the prediction of acute toxicity in man as evaluated on the first ten chemicals of the MEIC Programme
The acute toxicity data of the first 50 chemicals of the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) programme is compared for three "cyst-based toxicity tests" (Artoxkit M with Artemia salina, Streptoxkit F with Streptocephalus proboscideus, and Rotoxkit F with Brachionus calyciflorus), and two other tests (the Daphnia magna and the Photobacterium phosphoreum Microtox tests) commonly used in ecotoxicology. The difference in sensitivity for the 50 chemicals was as high as 19 orders of magnitude (on a molecular weight basis) between the most and least sensitive species. Generally, a similar toxicity ranking of the 5 test species was found for most of the chemicals and the interspecies correlations were high. Results from Principal Component Analysis (PCA) and cluster analysis indicated that the groupings are not related to a clear and defined chemical structure. However, the loading plot of the first two principal components may aid in selecting the minimum n 
Ecology; Ecology; Biochemical Studies-General; Toxicology-Environmental and Industrial Toxicology; Physiology and Biochemistry of Bacteria; In Vitro Studies; Public Health: Environmental Health-Air; Invertebrata; Invertebrata; Vibrionaceae (1992- ); Rotifera; Branchiopoda