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1061735 
Journal Article 
JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock 
Izumikawa, M; Ukai, H; Takagi, M; Ueda, HR; Shin-Ya, K 
2008 
Yes 
Journal of Antibiotics
ISSN: 0021-8820 
61 
12 
756-758 
English 
19194035 
In the course of our screening program for regulators of circadian clock system (circadian rhythms), we isolated a new natural compound JBIR-26 (1) from Streptomyces sp. AK-AH76. The structure was determined to be 2-hydroxy-3,6-dimethylbenzoic acid on the basis of spectroscopic data. Compound 1 lengthened the period-length of mammalian clocks for 1.5 hours at a concentration of 10 microg/ml. 
IRIS
• Trimethylbenzenes (TMB)