Venkat, RN; Benoy, K; Hemamalimi, K; Shanta Kumar, SM; Satyanarayana, S
The objective of the study is to investigate the anti inflammatory, analgesic, diuretic and anthelmintic activity of Pet ether (PETI), Chloroform (CHTI) and Aqueous (AQTI) extracts of roots of Tragia involucrata in rodents and earth worms. Roots were successively extracted with Pet ether, Chloroform and distilled water. Preliminary phytochemical investigation was carried out to identify various phytochemical constituents present in these extracts. LD SUB 50 of PETI, CHTI and AQTI were conducted as per OECD guidelines No 425. LD SUB 50 of PETI was 500mg/kg, for CHTI 500mg/kg and for AQTI 1000mg/kgrespectively. The various activities were assessed by anti-inflammatory activity with carrageenan induced rat paw oedema, analgesic activity by radiant heat induced nociception, diuretic activity by Lipschitz model and antihelmintic activity by earthworm model. The Preliminary phytochemical investigation revealed the presence of tannins and flavonoids in PETI, alkaloids in CHTI and alkaloids and saponins in AQTI extracts. All the three extracts exhibited anti-inflammatory, analgesic, diuretic and anthelmintic activities
alkaloid ,pharmacology ,pd; Alkaloids; analgesia; analgesic activity; anthelmintic activity; antiinflammatory activity; aqueous solution; article; Carrageenan; chloride ion ,endogenous compound ,ec; Chloroform; concentration; controlled study; diclofenac ,drug comparison ,cm; diclofenac ,drug therapy ,dt; diclofenac ,oral drug administration ,po; diuresis; drug dosage form comparison; earthworm; Embase 2007 to 04/30/08; ether; Euphorbia; evaluation; Female; flavonoid; flavonoid ,pharmacology ,pd; Flavonoids; furosemide ,drug comparison ,cm; furosemide ,drug therapy ,dt; Heat; India; LD 50; Male; nociception; nonhuman; paw edema ,drug therapy ,dt; pentazocine ,drug comparison ,cm; pentazocine ,drug therapy ,dt; pentazocine ,intraperitoneal drug administration ,ip; pharmacology; phosphorus ,endogenous compound ,ec; phytochemistry; piperazine ,drug comparison ,cm; piperazine ,pharmacology ,pd; plant extract ,drug comparison ,cm; plant extract ,drug therapy ,dt; plant extract ,pharmacology ,pd; plant root; potassium ion ,endogenous compound ,ec; rat; rodent; saponin ,pharmacology ,pd; sodium chloride; sodium ion ,endogenous compound ,ec; tannin; tannin derivative ,pharmacology ,pd; urinalysis; urine volume; Water