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Citation
Tags
HERO ID
1074813
Reference Type
Journal Article
Subtype
Review
Title
Antigen presentation and T cell stimulation by dendritic cells
Author(s)
Guermonprez, P; Valladeau, J; Zitvogel, L; Théry, C; Amigorena, S
Year
2002
Is Peer Reviewed?
Yes
Journal
Annual Review of Immunology
ISSN:
0732-0582
EISSN:
1545-3278
Volume
20
Page Numbers
621-667
Language
English
PMID
11861614
DOI
10.1146/annurev.immunol.20.100301.064828
Web of Science Id
WOS:000175012600021
Abstract
Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance.
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