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1074813 
Journal Article 
Review 
Antigen presentation and T cell stimulation by dendritic cells 
Guermonprez, P; Valladeau, J; Zitvogel, L; Théry, C; Amigorena, S 
2002 
Yes 
Annual Review of Immunology
ISSN: 0732-0582
EISSN: 1545-3278 
20 
621-667 
English 
11861614 
WOS:000175012600021 
Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance.