Health & Environmental Research Online (HERO)


Print Feedback Export to File
1075721 
Journal Article 
Review 
Journey through the thymus: stromal guides for T-cell development and selection 
Takahama, Y 
2006 
1 
Nature Reviews. Immunology
ISSN: 1474-1733
EISSN: 1474-1741 
6 
2 
127-135 
English 
16491137 
WOS:000234897700015 
Lympho-stromal interactions in multiple microenvironments within the thymus have a crucial role in the regulation of T-cell development and selection. Recent studies have implicated that chemokines that are produced by thymic stromal cells have a pivotal role in positioning developing T cells within the thymus. In this Review, I discuss the importance of stroma-derived chemokines in guiding the traffic of developing thymocytes, with an emphasis on the processes of cortex-to-medulla migration and T-cell-repertoire selection, including central tolerance.