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Citation
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HERO ID
1076422
Reference Type
Journal Article
Subtype
Review
Title
Enhancement of allergic inflammation by diesel exhaust particles: permissive role of reactive oxygen species
Author(s)
Casillas, AM; Hiura, T; Li, N; Nel, AE
Year
1999
Is Peer Reviewed?
Yes
Journal
Annals of Allergy, Asthma & Immunology
ISSN:
1081-1206
EISSN:
1534-4436
Volume
83
Issue
6 Pt 2
Page Numbers
624-629
Language
English
PMID
10619333
DOI
10.1016/S1081-1206(10)62884-0
Web of Science Id
WOS:000084429300011
Abstract
BACKGROUND: Diesel emission particulates (DEP) exert effects on the immune system and act as an adjuvant which enhances allergic inflammation. Animal and human models have delineated the effects of DEP chemicals in enhancing IgE production and promoting T-helper cell-2 (Th2) differentiation. An important primary effect that can explain the DEP-associated humoral and cellular immune responses is the induction of macrophage responses by DEP chemicals. This includes effects on macrophage production of cytokines and chemokines, which may play a role in enhancing allergic inflammation. A potent mechanism in macrophages exposed to DEP chemicals involves the generation of reactive oxygen species (ROS), leading to cellular activation or apoptosis which can be abrogated by antioxidants. CONCLUSION: These findings may establish a role for antioxidant therapy in diminishing the effects of particulate pollutants in asthma.
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