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Tags
HERO ID
1077512
Reference Type
Journal Article
Subtype
Review
Title
Integrins and adhesive receptors in normal and leukemic CD34+ progenitor cells: potential regulatory checkpoints for cellular traffic
Author(s)
Liesveld, JL; Dipersio, JF; Abboud, CN
Year
1994
Is Peer Reviewed?
1
Journal
Leukemia and Lymphoma
ISSN:
1042-8194
Volume
14
Issue
1-2
Page Numbers
19-28
Language
English
PMID
7522718
DOI
10.3109/10428199409049647
Abstract
Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the marrow microenvironment. This work characterizes the expression of various adhesive receptors on normal early hematopoietic precursors and reviews how they might be altered in leukemic states. Early hematopoietic CD34+ cells express CD18, CD11a, CD49d, CD49e, CD44, ICAM-1, and ICAM-3. Likewise, most AML samples express CD49d, CD49e, and CD44. In addition to mediating the adherence of progenitors to the marrow, these multiple receptors and their respective ligands may serve to regulate in vivo leukemic cell agrees from marrow and the ability of certain leukemic phenotypes to selectively seek extramedullary sanctuary sites such as the skin and the central nervous system.
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