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HERO ID
1088674
Reference Type
Journal Article
Title
Maternal or umblical venous levels of nitrite/nitrate during pregnancy and at delivery
Author(s)
Jo, T; Takauchi, Y; Nakajima, Y; Fukami, K; Kosaka, H; Terada, N
Year
1998
Is Peer Reviewed?
Yes
Journal
In Vivo
ISSN:
0258-851X
EISSN:
1520-4901
Volume
12
Issue
5
Page Numbers
523-526
Language
English
PMID
9827360
Web of Science Id
WOS:000076992200013
Abstract
OBJECTIVE:
This study was intended to measure serum concentrations of nitrite plus nitrate as an index of nitric oxide synthesis, in the maternal vein during pregnancy, just after a spontaneous delivery and at the puerperium, and at an elective cesarean section, and in the umblical vein and artery.
METHODS:
Maternal venous sera, and umblical venous and arterial sera were collected, and serum concentrations of nitrite/nitrate were measured by an automated procedure based on the Greiss reaction after reduction of nitrate to nitrite.
RESULTS:
Compared to a serum concentration of nitrite/nitrate at the first trimester (12-13 weeks of pregnancy), a serum concentration of nitrite/nitrate slightly increased at the second trimester (27-28 weeks), and became maximal at the third trimester (35-36 weeks), followed by a significant decrease near the term (38-40 weeks). A serum concentration of nitrite/nitrate slightly increased just after a spontaneous delivery with labor pains, and at the puerperium to levels slightly more than that at the first trimester. Serum concentrations of nitrite/nitrate in the umblical vein and artery did not differ. They were significantly higher than a serum concentration of nitrite/nitrate in the maternal vein just after a spontaneous delivery with labor pains but not at an elective cesarean section without labor pains.
CONCLUSION:
A decrease in maternal serum levels of nitrite/nitrate near term may support a hypothesis that NO is one of factors responsible for the maintenance of uterine quiescence during pregnancy. Moreover, the present results suggest that NO plays some role in the feto-placental circulation during a spontaneous delivery.
Keywords
NO; nitrite; nitrate; pregnancy; delivery; serum
Tags
•
Nitrate/Nitrite
ATSDR literature
Supplemental LitSearch Update 1600-2015
PubMed
WoS
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