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1088794 
Journal Article 
Review 
Role and regulation of nitric oxide in the uterus during pregnancy and parturition 
Yallampalli, C; Dong, YL; Gangula, PR; Fang, L 
1998 
1 
Journal of the Society for Gynecologic Investigation
ISSN: 1071-5576 
5 
2 
58-67 
English 
9509382 
WOS:000072092100002 
OBJECTIVE: To review the English-language literature as it relates to the role and regulation of uterine nitric oxide (NO) during pregnancy and parturition, special emphasis being placed on the interactions of NO with other uterotonic agents.

METHODS: A thorough literature review of the English-language literature using a Medline search was performed.

RESULTS: Current data support the view that NO is generated in the uterus and inhibits uterine contractility. Gestation, parturition, steroid hormones, and prostaglandins modulate both the generation and the effects of NO on the uterus. The changes in NO and its effects are consistent with the theory that NO plays a role in uterine quiescence during pregnancy. A change in this system at term or preterm could play a role in inhibition of labor and delivery.

CONCLUSION: Uterine NO may play a role in maintaining uterine quiescence during pregnancy. 
nitric oxide; nitric oxide synthase; prostaglandin; uterus; pregnancy; parturition; steroid hormones