US EPA

10898 

Journal Article 

Effect of carbon monoxide on oxygen transport during exercise 

Vogel, JA; Gleser, MA 

1972 

Yes 

Journal of Applied Physiology (1985)
ISSN: 8750-7587
EISSN: 1522-1601 

HEEP/72/08554 

32 

2 

234-239 

English 

4550276 

10.1152/jappl.1972.32.2.234 

WOS:A1972L639500017 

Oxygen (O2) transport was studied in eight men at rest and during submaximal and maximal work while exposed to air and a 225-ppm carbon monoxide (CO)-air mixture. The latter resulted in a carboxyhemoglobin saturation of 18-20% with no change in the arterial O2 tension. During CO inhalation, resting oxygen uptake was maintained with unchanged cardiac output and unchanged arteriovenous difference, although arterial and venous oxygen contents were lower. During submaximal exercise, O2 delivery was maintained with greater cardiac output but smaller arteriovenous O2 difference as compared to normoxic controls. During maximal work, cardiac output was no greater and mixed venous O2 content no less than in normoxic and, and a result maximal O2 uptake fell by 23%, i.e., proportional to the arterial desaturation. This indicates that the leftward shift of the oxyhemoglobin dissociation curve which accompanies CO exposure is compensated for by lower venous O2 tension so that O2 transport capacity is not different from that seen in hypoxic hypoxia. 

hypoxia; oxygen extraction