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1091179 
Journal Article 
Acute toxicity study of the interaction between titanium dioxide nanoparticles and lead acetate in mice 
Zhang, R; Niu, YJ; Li, YW; Zhao, CF; Song, B; Li, Y; Zhou, YK 
2010 
Yes 
Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 
30 
1 
52-60 
English 
21787629 
WOS:000279089000009 
Titanium dioxide (TiO(2)) is one kind of widely used nanoparticle, which was used as a solid-phase extraction to preconcentrated and measured of lead (Pb) in river water and seawater. However the interaction of nanoparticle TiO(2) and Pb was unknown. The aim of this study is to investigate the potential acute toxicity of the interaction between nanoparticle TiO(2) (50 and 120 nm) and lead acetate (PbAC) in adult mice. The animals were randomly divided into six groups: a control group and five treatment groups (TiO(2)-50, TiO(2)-120, PbAC, TiO(2)-50 + PbAC and TiO(2)-120 + PbAC groups). Suspensions of TiO(2) (5 g/kg body weight), PbAC (500 mg/kg body weigh) and TiO(2) (5 g/kg body weight)+ PbAC (500 mg/kg body weigh) were administrated to mice via oral gavage, respectively. Seven days later, the animals were sacrificed after being anesthetized by ether. There were no significant changes of the body weight coefficients of liver, kidney and brain. However, the results of liver function and nephrotoxicity examination revealed that there were serious damages to liver and kidney between the group treated with the mix suspension and the one with TiO(2). After the mix suspension treatment, ROS levels were significantly increased in liver but not in kidney, cortex and hiocampus. There were no increase of MDA levels in these tissues, and no activity reductions of SOD and GSH-Px in liver and kidney but in the cortex and hippocampus. Therefore, though our results have not suggested that TiO(2) particle and PbAC have a synergistic acute toxicity in mice after oral administration. PbAC may increase the acute toxicity of TiO(2) nanoparticle in some degree. The potential toxic mechanism maybe related with oxidative damages. (C) 2010 Elsevier B.V. All rights reserved. 
Titanium dioxide; Nanoparticles; Lead acetate; Interacted acute toxicity; Oxidative damages