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1095870 
Journal Article 
The autonomic innervation of the uterus A short review on pharmacological aspects 
Tica, AA; Dun, E; Tica, V; Cojocaru, V; Tica, OS; Berceanu, S 
2011 
7 
2 
86-91 
English 
WOS:000295380200004 
Despite the important volume of data regarding the physiology and pharmacology of uterine smooth muscle innervation, it is unclear the precise role of the nervous suly on myometrial activity. Moreover, although all uterine myocytes possess specific adrenergic and cholinergic receptors, the autonomic fibers are almost exclusively distributed to cervix (eventually to isthmus, which becomes the lower uterine segment in the last part of the pregnancy), where is located less that 10% of the whole myometrium. It seems that neuronal modulation is implicated more on cervical dynamics and poorly on "effective" uterine contractility. It is important to note that constantly there is a neuronal co-transmission, either sympathetic or parasympathetic, or even non-adrenergic/non-cholinergic mediation, the number of discovered compounds, able to modulate the uterine activity, increasing permanently. Must be mentioned, also, the variability of receptors either as density, sensitivity or intracellular pathways, depending of hormonal impregnation, especially on gestation. Furthermore, during pregnancy, placenta and amniotic membranes possess a strong impact on myometrium, connective tissue, but also on neuronal ending characteristics. 
sympathetic; parasympathetic; co-transmission; non-adrenergic non-cholinergic