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11686 
Book/Book Chapter 
Inflammatory cells of the lung: macrophages 
Holian, A 
1997 
Elsevier Science, Inc 
New York, NY 
Comprehensive toxicology: v. 8, toxicology of the respiratory system 
The alveolar macrophage is responsible for maintaining the sterile environment of the lungs. This is accomplished in concert with other immune cells and neutrophils. Due to its important functions and location in the lungs the macrophage is a critical target for xenobiotic-mediated lung injury. Xenobiotic agents have been implicated in various forms of lung injury from inducing immunosuppression to chronic inflammation through effects on the alveolar macrophage. Although a great deal of information has been obtained, more questions remain. There are still undiscovered cytokines and even responses of the alveolar macrophage, as well as mechanisms of xenobiotic action that will alter our thinking in the future. 
Sipes, I. G.; McQueen, C. A.; Gandolfi, A. J.; Roth, R. A.